The RPG elements gel extremely well, the branching and exclusive paths of upgrades allowing you to modify kit according to your play style. To balance that, weapons and armour that are heavily degraded can't be sold until repaired. Repairs and modifications are pricey too, but making money is nowhere near as hard as it has been in the last two games, with artefacts now fetching extremely high prices. The weapon and suit repair and upgrade system has been polished nicely, with technicians requiring sets of tools to perform the modifications which increase rates of fire, accuracy or armour ratings. The small boosts to resistance you'll gain from them will probably only see any use at the beginning before you're kitted out with a decent suit, but they're a nice addition.
Meds are pre-emptive items which increase resistances, load-capacity or healing rate, even allowing you to survive the lethal radioactive emissions which periodically sweep the Zone. In preparation for this dangerous harvest, you'll probably want to take advantage of one of Call of Pripyat's new toys, the medication system.